Probabilistic safety and optimal control for survival analysis of Bacillus subtilis

نویسندگان

  • Alessandro Abate
  • John Lygeros
  • S. Shankar Sastry
چکیده

This work investigates the problem of determining switching conditions for the production of the lantibiotic subtilin by Bacillus subtilis. These conditions are synthesized as the outcome of an optimal control problem based on a survival analysis interpretation. The problem is built upon the general modeling framework of stochastic hybrid systems, by translating the survival analysis into a probabilistic optimal safety verification procedure.

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عنوان ژورنال:
  • Systems & Control Letters

دوره 59  شماره 

صفحات  -

تاریخ انتشار 2010